AffiAAV® rAAV-hSyn-EYFP-WPRE-bGH polyA

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CAT# AFG-BRV-0034
Size: 1 Unit

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rAAV-hSyn-EYFP-WPRE-bGH polyA

rAAV-hSyn-EYFP-WPRE-bGH polyA is a recombinant adeno-associated virus (rAAV) vector designed for targeted gene delivery. Here are the key components and features:

  • Human Synapsin I Promoter (hSyn): Drives expression specifically in neurons.
  • EYFP (Enhanced Yellow Fluorescent Protein): Used for visualizing expression.
  • WPRE (Woodchuck Hepatitis Virus Post-transcriptional Regulatory Element): Enhances transgene expression.
  • bGH polyA (Bovine Growth Hormone Polyadenylation Signal): Ensures proper termination of transcription.

Application of rAAV-hSyn-EYFP-WPRE-bGH polyA

This rAAV vector is primarily used in neuroscience research for robust gene expression and visualization of neurons. The hSyn promoter ensures neuron-specific expression, making it suitable for various studies on neural circuits, neuronal development, and behavior.


Advantage of rAAV-hSyn-EYFP-WPRE-bGH polyA

The combination of the hSyn promoter and EYFP allows for high-level, neuron-specific expression of the transgene, with the added benefit of fluorescence for easy visualization. The inclusion of WPRE enhances overall expression levels, and the bGH polyA ensures proper transcription termination. This vector is a powerful tool for neuroimaging and functional studies, providing precise control over neuronal labeling with high specificity and efficiency.


Detailed Applications of rAAV-hSyn-EYFP-WPRE-bGH polyA

  1. Neuronal Labeling:
    • Enables precise labeling of neurons for studying their morphology and connectivity.
    • Suitable for tracing individual neurons and their processes in complex neural networks.
  2. Neuroscience Research:
    • Facilitates the study of neuronal development, synaptic plasticity, and neural circuit dynamics.
    • Useful for investigating the role of specific neuronal populations in behavior and brain function.
  3. Fluorescent Imaging:
    • EYFP allows for visualization of infected neurons under a fluorescence microscope.
    • Aids in verifying transduction efficiency and expression patterns.
  4. Behavioral Studies:
    • Helps in linking specific neuronal activity to behavioral outcomes.
    • Can be used to manipulate and observe changes in behavior following targeted neuronal labeling.
  5. Disease Models:
    • Can be used to model neurological diseases where specific neuronal populations are affected.
    • Useful in preclinical research for developing therapeutic strategies targeting specific neurons.
  6. Neural Circuit Mapping:
    • Allows for tracing and understanding the connections and interactions between neurons.
    • Combined with other techniques, it can reveal functional connectivity in the brain.

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