rAAV-GFAP

The GFAP promoter is derived from the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament protein predominantly expressed in astrocytes, a key glial cell type in the central nervous system (CNS). Recombinant adeno-associated viruses (rAAVs) utilizing the GFAP promoter are specifically designed for astrocyte-specific gene expression.

Features of rAAV-GFAP
  • Cell-Type Specificity:
    • The GFAP promoter drives transgene expression specifically in astrocytes, ensuring targeted manipulation of these glial cells.
  • Central Nervous System Targeting:
    • Effective in brain and spinal cord astrocytes, making it a key tool for neuroscience research.
  • Long-Term Expression:
    • rAAV-mediated delivery provides stable and persistent transgene expression in astrocytes.
  • Tissue-Specific Application:
    • Ideal for studies focused on astrocyte functions in neural circuits, metabolic support, and neuroinflammation.
Applications of rAAV-GFAP
  • Astrocyte-Specific Research:
    • Circuit Modulation: Expression of optogenetic or chemogenetic tools (e.g., halorhodopsins, DREADDs) to study astrocyte contributions to neural activity and behavior.
    • Calcium Imaging: Delivery of calcium indicators (e.g., GCaMP) to monitor astrocytic activity during physiological or pathological states.
  • Neurodegenerative Diseases:
    • Investigating astrocyte involvement in diseases like Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis (ALS).
    • Delivery of therapeutic genes targeting astrocyte-mediated neuroinflammation or metabolic dysfunction.
  • Glial-Neuronal Interactions:
    • Studying the role of astrocytes in synaptic plasticity, neurotransmitter clearance, and blood-brain barrier maintenance.
  • Gene Therapy:
    • Astrocyte-specific expression of therapeutic proteins, neurotrophic factors, or enzymes to support neuronal survival or modulate disease pathways.

rAAV-GFAP is an essential tool for targeting astrocytes in neuroscience and gene therapy. It enables specific investigation of astrocyte functions and their roles in CNS health and disease. Its high specificity and stable expression make it invaluable for both basic research and therapeutic development.

AffiAAV® rAAV-GFAP104-EYFP-WPRE-hGH polyA
CAT# AFG-BRV-0099
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-mito-mCherry-WPRE-hGH polyA
CAT# AFG-BRV-0098
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-mCherry-P2A-mCherry-WPREs
CAT# AFG-BRV-0097
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-tdTomato-WPRE-hGH polyA
CAT# AFG-BRV-0096
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-mcherry-WPRE-hGH polyA
CAT# AFG-BRV-0094
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0093
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-3XFlag-WPRE-hGH polyA
CAT# AFG-BRV-0092
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-EYFP-WPRE-hGH polyA
CAT# AFG-BRV-0091
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-eNpHR3.0-EYFP-WPREs
CAT# AFG-BRV-1289
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-eNpHR3.0-EYFP-WPRE-hGH polyA
CAT# AFG-BRV-1288
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-hChR2(H134R)-EGFP-WPREs
CAT# AFG-BRV-1133
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
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AffiAAV® rAAV-GFAP(681)-Cre-WPRE-hGH polyA
CAT# AFG-BRV-1015
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-Cre-EYFP-WPREs
CAT# AFG-BRV-1014
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-Cre-EGFP-WPREs
CAT# AFG-BRV-1013
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-Cre-3XFlag-WPRE-hGH polyA
CAT# AFG-BRV-1012
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-Cre-WPRE-hGH polyA
CAT# AFG-BRV-1011
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-NES-jRCaMP1a-WPRE-hGH polyA
CAT# AFG-BRV-0909
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-jGCaMP7c variant 1513-WPREs
CAT# AFG-BRV-0857
Size: 1 Unit
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AffiAAV® rAAV-GFAP-GCaMP6s-WPRE-hGH polyA
CAT# AFG-BRV-0784
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-hM4D(Gi)-mCherry-WPREs
CAT# AFG-BRV-0702
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
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AffiAAV® rAAV-GFAPABC1D-hM3D(Gq)-mCherry-WPREs
CAT# AFG-BRV-0629
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP(681)-hM3D(Gq)-mCherry-WPREs
CAT# AFG-BRV-0626
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-EGFP-T2A-TVA-WPRE-hGH polyA
CAT# AFG-BRV-0512
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP-rTTA-3XFlag-WPREs
CAT# AFG-BRV-0364
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-GFAP104-tTA-P2A-mCherry-hGH polyA
CAT# AFG-BRV-0344
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD