rAAV-CaMKlla

Recombinant adeno-associated viruses (rAAVs) are widely used as vectors for gene delivery in neuroscience and related fields. The CaMKIIα promoter, derived from the gene encoding calcium/calmodulin-dependent protein kinase II alpha, is a neuron-specific promoter commonly used for targeting excitatory neurons.

Features of rAAV-CaMKIIα
  • Neuron-Specific Expression:
    • The CaMKIIα promoter ensures gene expression is restricted primarily to excitatory neurons in the central nervous system (CNS).
    • Minimal expression in glial cells or inhibitory neurons, improving targeting specificity.
  • Activity-Dependent Targeting:
    • CaMKIIα expression is regulated by neuronal activity, making it suitable for studies on active neural circuits.
  • Efficiency:
    • Supports high-level, long-term expression of transgenes in neurons.
Applications of rAAV-CaMKIIα
  • Neuroscience Research:
    • Optogenetics: Delivery of channelrhodopsins or halorhodopsins to modulate excitatory neural activity.
    • Calcium Imaging: Expression of fluorescent calcium indicators (e.g., GCaMP) to monitor neuronal activity.
    • Behavioral Studies: Manipulation of specific neural circuits to study their roles in learning, memory, and behavior.
  • Gene Therapy:
    • Experimental treatment of CNS disorders where excitatory neurons are implicated (e.g., epilepsy, stroke recovery).
  • Circuit Mapping:
    • Tracing synaptic connections using retrograde or anterograde tracers under the CaMKIIα promoter.
    • Identifying functional contributions of excitatory neurons in specific brain regions.
  • Functional Genomics:
    • Overexpression or silencing of genes specifically in excitatory neurons to study gene function.
    • Targeted CRISPR/Cas9 genome editing in excitatory neurons.

rAAV-CaMKIIα is a precise and efficient tool for studying excitatory neuron function, mapping neural circuits, and developing targeted therapeutic strategies for CNS disorders. It has become a cornerstone in the field of neuroscience.

AffiAAV® rAAV-CaMKIIa-DIO-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0196
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-CaMKIIa-DIO-EGFP-WPREs
CAT# AFG-BRV-0195
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-DIO-mCherry-WPRE-hGH polyA
CAT# AFG-BRV-0194
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-DO-mCherry-WPRE-hGH polyA
CAT# AFG-BRV-0187
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-DO-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0186
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-soma-tDtomato-WPREs
CAT# AFG-BRV-0056
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-mcherry-kir2.1-WPREs
CAT# AFG-BRV-0055
Size: 1 Unit
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CAT# AFG-BRV-0054
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-BFP-WPRE-hGH polyA
CAT# AFG-BRV-0053
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-Mito-dsRed-WPRE-hGH polyA
CAT# AFG-BRV-0052
Size: 1 Unit
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AffiAAV® rAAV-CaMkIIa-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0051
Size: 1 Unit
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AffiAAV® rAAV-CAMKIIa-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0050
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-mCherry-WPRE-hGH polyA
CAT# AFG-BRV-0049
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-EYFP-WPRE-hGH polyA
CAT# AFG-BRV-0048
Size: 1 Unit
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CAT# AFG-BRV-1339
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CAT# AFG-BRV-1260
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-C1V1-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-1246
Size: 1 Unit
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CAT# AFG-BRV-1204
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-hChR2(H134R)-BFP-WPREs
CAT# AFG-BRV-1130
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-Flp-WPRE-hGHpA
CAT# AFG-BRV-1094
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-Flp-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-1093
Size: 1 Unit
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AffiAAV® rAAV-CaMkIIa-Cre-GCaMP6S-WPREs
CAT# AFG-BRV-0962
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-GCaMP6f-P2A-Cre-WPREs
CAT# AFG-BRV-0961
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-DsRed-Cre-WPRE-hGH polyA
CAT# AFG-BRV-0960
Size: 1 Unit
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CAT# AFG-BRV-0959
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-Cre-WPRE-hGH polyA
CAT# AFG-BRV-0956
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-jRGECO1a-WPRE-hGH polyA
CAT# AFG-BRV-0897
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-SomaGCaMP7b-WPRE-hGH pA
CAT# AFG-BRV-0863
Size: 1 Unit
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CAT# AFG-BRV-0861
Size: 1 Unit
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AffiAAV® rAAV-CaMkIIa-Cre-GCaMP6S-WPREs
CAT# AFG-BRV-0782
Size: 1 Unit
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CAT# AFG-BRV-0781
Size: 1 Unit
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CAT# AFG-BRV-0780
Size: 1 Unit
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CAT# AFG-BRV-0779
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-GCaMp6f-WPRE-hGH polyA
CAT# AFG-BRV-0777
Size: 1 Unit
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CAT# AFG-BRV-0776
Size: 1 Unit
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CAT# AFG-BRV-0775
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-DIO-GCaMp6s-WPRE-hGH polyA
CAT# AFG-BRV-0745
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-hM4D(Gi)-EGFP-WPREs
CAT# AFG-BRV-0700
Size: 1 Unit
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CAT# AFG-BRV-0698
Size: 1 Unit
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AffiAAV® rAAV-CAMKIIa-fDIO-hM4D(Gi)-EYFP-WPREs
CAT# AFG-BRV-0686
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-DIO-hM4D(Gi)-EGFP-WPREs
CAT# AFG-BRV-0661
Size: 1 Unit
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AffiAAV® rAAV-CaMkIIa-hM3D(Gq)-P2A-EGFP-WPREs
CAT# AFG-BRV-0625
Size: 1 Unit
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CAT# AFG-BRV-0624
Size: 1 Unit
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AffiAAV® rAAV-CAMKIIa-fDIO-hM3D(Gq)-EGFP-WPREs
CAT# AFG-BRV-0612
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-DO-hM3D(Gq)-mCherry-WPREs
CAT# AFG-BRV-0606
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-DIO-hM3D(Gq)-EGFP-WPREs
CAT# AFG-BRV-0585
Size: 1 Unit
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AffiAAV® rAAV-CaMkIIa-Tau-tdtomato-WPREs
CAT# AFG-BRV-0531
Size: 1 Unit
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AffiAAV® rAAV-CaMKIIa-tau-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0528
Size: 1 Unit
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