rAAV-Regulatory Elements hGH polyA

The hGH polyadenylation (PolyA) signal is a regulatory element derived from the human growth hormone gene. It plays a crucial role in post-transcriptional regulation in gene therapy and recombinant adeno-associated virus (rAAV) systems. The hGH PolyA ensures efficient transcription termination, mRNA processing, and stable gene expression.

Structure and Role of hGH PolyA:
  • Polyadenylation:
    • Adds a poly(A) tail to the 3' end of mRNA, protecting it from degradation.
  • Transcription Termination:
    • Provides a termination signal for RNA polymerase II, ensuring clean transcript ends.
  • Enhanced Expression:
    • Ensures proper splicing, export of mRNA to the cytoplasm, and efficient translation.
  • Stability and Functionality:
    • Improves the stability of therapeutic mRNA and protein production.
Advantages of Using hGH PolyA in rAAV Vectors:
  • High Efficiency:
    • Supports strong and reliable gene expression in various cell types and tissues.
  • Human-Derived:
    • Reduces potential immunogenicity, making it particularly suitable for clinical applications.
  • Broad Applicability:
    • Functional across multiple rAAV platforms, including tissue-specific and systemic gene delivery systems.
Applications in Gene Therapy:
  • Therapeutic Protein Expression:
    • Used in rAAV vectors delivering proteins such as clotting factors (e.g., hemophilia treatments) or enzymes for metabolic disorders.
  • Neurological Diseases:
    • Ensures stable transgene expression in neurons for conditions like Parkinson's disease and spinal muscular atrophy (SMA).
  • Ophthalmic Gene Therapy:
    • Provides sustained expression for treating retinal degenerative diseases.

The hGH polyA signal is a cornerstone in rAAV vector design, offering robust and stable post-transcriptional regulation. Its effectiveness in supporting efficient and sustained gene expression makes it indispensable for advancing gene therapy technologies.

AffiAAV® rAAV-nEF1a-fDIO-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0262
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-nEF1a-fDIO-mCherry-WPRE-hGH polyA
CAT# AFG-BRV-0261
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-mDlx-DIO-EYFP-WPRE-hGH polyA
CAT# AFG-BRV-0254
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-mDlx-DIO-mCherry-WPRE-hGH polyA
CAT# AFG-BRV-0252
Size: 1 Unit
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AffiAAV® rAAV-mDlx-DIO-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0251
Size: 1 Unit
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AffiAAV® rAAV-nEF1a-DIO-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0191
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-cFos-D2mCherry-WPRE-hGH polyA
CAT# AFG-BRV-0170
Size: 1 Unit
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AffiAAV® rAAV-cFos-mCherry-WPRE-hGH polyA
CAT# AFG-BRV-0169
Size: 1 Unit
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AffiAAV® rAAV-cFos-D2EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0168
Size: 1 Unit
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AffiAAV® rAAV-cFos-mCherry-WPRE-hGH polyA
CAT# AFG-BRV-0167
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-cFos-EYFP-WPRE-hGH polyA
CAT# AFG-BRV-0166
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-CRH-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0125
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-CRH-EYFP-WPRE-hGH polyA
CAT# AFG-BRV-0124
Size: 1 Unit
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AffiAAV® rAAV-ChaT-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0113
Size: 1 Unit
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AffiAAV® rAAV-nEF1a-EGFP-3XFlag-WPRE-hGH polyA
CAT# AFG-BRV-0004
Size: 1 Unit
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AffiAAV® rAAV-ChaT-eNpHR3.0-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-1300
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-mDLx-eNpHR3.0-EYFP-WPRE-hGH polyA
CAT# AFG-BRV-1296
Size: 1 Unit
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AffiAAV® rAAV-cFos-Flp-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-1098
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-CRH-Cre-mCherry-WPRE-hGH polyA
CAT# AFG-BRV-1051
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-CRH-Cre-WPRE-hGH polyA
CAT# AFG-BRV-1049
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
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AffiAAV® rAAV-ChAT-Cre-P2A-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-1008
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-ChAT-Cre-WPRE-hGH polyA
CAT# AFG-BRV-1007
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-mDLx-Cre-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0988
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-mDlX-Cre-WPRE-hGH polyA
CAT# AFG-BRV-0987
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-cFos-Cre-WPRE-hGH polyA
CAT# AFG-BRV-0968
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-ChaT-jRCaMP1a-WPRE-hGH polyA
CAT# AFG-BRV-0912
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-mDLx-DIO-jRGECO1a-WPRE-hGH polyA
CAT# AFG-BRV-0896
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-mDlx-NES-jRGECO1a-WPRE-hGH polyA
CAT# AFG-BRV-0891
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
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AffiAAV® rAAV-CRH-GCaMP6s-WPRE-hGH polyA
CAT# AFG-BRV-0806
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-mDLx-GCaMp6m-WPRE-hGH polyA
CAT# AFG-BRV-0794
Size: 1 Unit
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AffiAAV® rAAV-mDlx-GCaMP6f-WPRE-hGH polyA
CAT# AFG-BRV-0793
Size: 1 Unit
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AffiAAV® rAAV-mDLx-GCaMP6s-WPRE-hGH polyA
CAT# AFG-BRV-0792
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-nEF1a-fDIO-GCaMp6m-WPRE-hGH polyA
CAT# AFG-BRV-0757
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-nEF1a-fDIO-GCaMp6f-WPRE-hGH polyA
CAT# AFG-BRV-0756
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-CRH-DIO-GCaMp6m-WPRE-hGH polyA
CAT# AFG-BRV-0752
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-mDlx-DIO-GCaMP6s-WPRE-hGH polyA
CAT# AFG-BRV-0748
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
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AffiAAV® rAAV-nEF1a-fDIO-TVA-EGFP-WPRE-hGH polyA
CAT# AFG-BRV-0493
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
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AffiAAV® rAAV-CRH-DIO-oRVG-WPRE-hGH polyA
CAT# AFG-BRV-0438
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-CRH-WGA-CRE-WPRE-hGH polyA
CAT# AFG-BRV-0414
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-cFos-ERT2CreERT2-WPRE-hGH polyA
CAT# AFG-BRV-0375
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-cFos-rTTA-WPRE-hGH polyA
CAT# AFG-BRV-0362
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
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AffiAAV® rAAV-cFos-DIO-TTA-WPRE-hGH polyA
CAT# AFG-BRV-0352
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-cFos-tTA-WPRE-hGH polyA
CAT# AFG-BRV-0350
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD
AffiAAV® rAAV-cFos-TTA-DD-WPRE-hGH polyA
CAT# AFG-BRV-0319
Size: 1 Unit
For Price Contact info@affigen.com 0.0 USD